Volume 11 Issues 2 February, 2021
Across
2. 40-year-old male patient presents with worsening neurological symptoms and sudden jerky movements. History of similar symptoms in patient’s father. This disease is characterised by abnormal expansion of what repetitive sequences?
4. 9-year-old boy is brought to the office for a well-child examination. Parents give history of poor scholastic performance by patient. There is history of the child creating a ruckus in class and not listening to the teacher. Child is known to be “energetic” at home as well and he never rests. Diagnosis?
8. 5-year-old boy is brought with complaints of lack of balance while walking. Review of symptoms shows this lack of balance has progressed. He also has minimal slurring of speech. After genetic testing, it is determined that there is a defective FXN gene. Diagnosis?
9. 4-year-old female, who was on the 50th centile for height and weight and was developing suitably was brought in to the office with developmental delay since a year. Mother also gives history of child waving her arm continuously without stopping and also resorts to head banging similarly. On examination patient is noted to have microcephaly and stunted growth. What syndrome is this?
10. 50-year-old male patient on treatment with IV Risperidone for acute psychosis has fever (104 F), delirium and rigidity in all extremities. Patient is started on a drug that decreases intracellular calcium concentration. That drug is?
Down
1. 68-year-old male patient with history of cerebrovascular accident, is brought by his son with complaints that the patient has been very forgetful over the last 2 years, even forgetting who his son is lately. There is 40-year pack history. On examination, patient has mild tremors with decreased deep tendon reflexes of all extremities (grade 2/5). Diagnosis?
3. 50-year-old female presents with pain and stiffness in all her joints, with history also suggestive of depression. Patient is unable to perform her day job properly. On examination, there are multiple points of tenderness over soft tissue both in upper and lower limbs. Diagnosis?
5. 55-year-old male is brought to the hospital with significant memory impairment. History suggests intellectual disability, congenital cardiac anomalies with patient having flat facies, epicanthic folds and oblique fissures. Patient is diagnosed with early onset Alzheimer’s disease. What predisposed the patient to Alzheimer’s?
6. 30-year-old male patient, comes with history of involuntary shaking of his leg when he is asleep. Symptoms have been present for a few months and patient claims that walking around during an episode makes him feel better. Patient is started on a drug that selectively stimulates dopamine D2 receptors
7. 29-year-old pregnant female with period of gestation 12 weeks, is diagnosed with bipolar disorder and is started on a medication that is safest during pregnancy. What drug is this?
ANSWER
Across
2. CAG
4. ADHD
8. FRIEDREICH ATAXIA
9. RETT SYNDROME
10. DANTROLENE
Down
1.VASCULAR DEMENTIA
3. FIBROMYALGIA
5. DOWN’S SYNDROME
6. ROPINIROLE
7. LAMOTRIGINE
By Dr. Ramaswamy Sundararajan
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